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Feature

07 December 2014 0 Comments

 

 

 

A new study shows that vitamin B12 may protect against Alzheimer's disease, adding more evidence to the scientific debate about whether the vitamin is effective in reducing the risk of memory loss. The research will be published in the October 19, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.

"Our findings show the need for further research on the role of vitamin B12 as a marker for identifying people who are at increased risk of Alzheimer's disease," said study author Babak Hooshmand, MD, MSc, with Karolinska Institutet in Stockholm, Sweden. "Low levels of vitamin B12 are surprisingly common in the elderly. However, the few studies that have investigated the usefulness of vitamin B12 supplements to reduce the risk of memory loss have had mixed results."

For the seven-year study, researchers took blood samples from 271 Finnish people age 65 to 79 who did not have dementia at the start of the study. During that time, 17 people developed Alzheimer's disease. Blood samples were tested for levels for homocysteine, an amino acid associated with vitamin B12, and for levels of the active portion of the vitamin, called holotranscobalamin. Too much homocysteine in the blood has been linked to negative effects on the brain, such as stroke. However, higher levels of vitamin B12 can lower homocysteine.

The study found that for each micromolar increase in the concentration of homocysteine, the risk of Alzheimer's disease increased by 16 percent, whereas each picomolar increase in concentration of the active form of vitamin B12 reduced risk by two percent. The results stayed the same after taking into account other factors, such as age, gender, education, smoking status, blood pressure and body mass index. The addition of folate did not appear to raise or lower the risk of Alzheimer's disease.

"More research is needed to confirm these findings before vitamin B12 should be used solely as a supplement to help protect memory," said Hooshmand.

Vitamin B12 can be found in fish, poultry and other meat products.

 

 

 

Feature

17 November 2014 0 Comments

 

 

 

Calcium and vitamin D are essential to keeping bones strong, dense and healthy as we age, as well as preventing bone loss, osteporosis, and skeletal fractures. Calcium builds and maintains healthy bones and vitamin D assists with absorption and increased uptake.

Alarmingly, 90 percent of women in the U.S. are deficient in calcium and 50 to 90 percent are deficient in vitamin D. These numbers are even higher among minorities, including Hispanics and African-Americans. Even among children, 30 to 40 percent are already deficient in calcium and vitamin D. Furthermore, about 50 percent of women and 20 percent of men aged 50 and older will have a fracture as a result of osteoporosis.

Clinicians and patients have become concerned about the possible, but unproven links between calcium supplements and heart attacks. In an editorial published in the current issue of the Journal of Cardiovascular Pharmacology and Therapeutics, E. Joan Barice, M.D., M.P.H., affiliate associate professor, and Charles H. Hennekens, M.D., Dr.P.H., first Sir Richard Doll professor and senior academic advisor to the dean in the Charles E. Schmidt College of Medicine at Florida Atlantic University, provide reassurances to clinicians and their patients about calcium and vitamin D supplements and cardiovascular disease.

The authors emphasize that the benefits of calcium and vitamin D supplements on bone health are conclusive, and that the totality of evidence is reassuring on cardiovascular disease. The totality of evidence includes all sources of information whether basic or clinical research, especially studies designed to test the question. Previous concerns were based largely on over-interpretation of results from studies not designed to test the question as well as overreliance on a few sub-groups of individual studies rather than looking at the totality of evidence.

To decrease disability and death from osteoporosis, many guidelines recommend daily intakes of 1,200 mg of calcium and 600 IU (international units) of vitamin D.

Hennekens and Barice conclude that it would be unfortunate if clinicians failed to prescribe the combination of calcium and vitamin D supplements as adjuncts to therapeutic lifestyles changes of proven benefit, especially regular physical activity, to the very large number of patients in whom the benefit-to-risk ratio in clearly favorable.

"While drugs to prevent and treat osteoporosis serve as bricks in strengthening bones and preventing bone loss, calcium and vitamin D serve as mortar," said Hennekens. "Without adequate intake of this combination, as recommended by most guidelines, we can neither achieve nor maintain healthy bone structure."

Barice has been a national leader in women's health as well as addiction medicine. She established the Florida Society of Addiction Medicine and achieved designation of the specialty by the Florida Medical Association and subsequent recognition by the American Medical Association. Her numerous other accomplishments benefiting public health include chronic pain management and the appropriate use of alternative and complementary medicines.

Hennekens has received numerous recent honors including the 2013 Fries Prize for Improving Health for his seminal contributions to the treatment and prevention of cardiovascular disease, the 2013 Presidential Award from his alma mater, Queens College, for his distinguished contributions to society, the 2013 honoree as part of FAU's Charles E. Schmidt College of Medicine from the American Heart Association for reducing deaths from heart attacks and strokes, and the 2014 Ochsner Award on cigarette smoking and disease. From 1995 to 2005, Science Watch ranked Hennekens as the third most widely cited medical researcher in the world and five of the top 20 were his former trainees and/or fellows. In 2012, Science Heroes ranked Hennekens No. 81 in the history of the world for having saved more than 1.1 million lives.

 

 

 

Feature

29 October 2014 0 Comments

 

 

 


In an article published in this month's issue of Pediatrics In Review, researchers from Boston University School of Medicine (BUSM) stress the importance of physicians recognizing that many mothers use herbal supplements while breastfeeding in order to make accurate health assessments for both mother and child.

In the US, no existing regulatory guidelines set a standardized risk assessment of herbal supplement use during breastfeeding. Because of the highly limited number of studies on herb use during lactation, numerous resources have mixed reports and safety recommendations, making it confusing for both mother and clinician.

After completing a systematic review of human lactation and herbal medicine literature, the researchers found poor methodology in the few available studies and concluded that further research is needed to assess the prevalence, efficacy and safety of commonly used herbs during breastfeeding.

"It is important for physicians and clinicians to be more aware that mothers are using herbal supplements and how vital it is to ask the mothers, who are seeking a doctor's opinion when having trouble breastfeeding, about their use before making an assessment," said senior author Paula Gardiner, MD, MPH, assistant professor at BUSM and a physician of family medicine at Boston Medical Center.

Although there is little scientific evidence to support the efficacy or safety of herbal supplements, it is a common practice both nationally and internationally.

"The use of herbal supplements while breastfeeding is two-sided-there are benefits, but there are also safety concerns," she added. "About 18 percent of the US population use herbs and dietary supplements. We just want to make sure physicians and clinicians are aware of this prevalent use when communicating with breastfeeding mothers about their health."

Herbal remedies may be used to increase the milk supply, relieve engorgement, treat mastitis, or for other therapeutic uses unrelated to lactation.

"Since there is very limited research, it is difficult to develop accurate information on the safety and effectiveness of specific herbs during breastfeeding," said Gardiner. "It is crucial that more research is conducted in this area, including national prevalence studies and safety and efficacy studies."
Source:

Boston University Medical Center

 

 

 

Feature

03 December 2014 0 Comments

 

 

 

A study conducted in more than 100 Mongolian schoolchildren found that daily treatment with a vitamin D supplement significantly reduced the symptoms of winter-related atopic dermatitis, a type of eczema. Led by a Massachusetts General Hospital (MGH) physician, the report in the October issue of the Journal of Allergy and Clinical Immunology supports the results of a preliminary study that showed similar results in a small group of children in Boston.

"While we don't know the exact proportion of patients with atopic dermatitis whose symptoms worsen in the winter, the problem is common," says Carlos Camargo, MD, DrPH, MGH Department of Emergency Medicine. "In this large group of patients, who probably had low levels of vitamin D, taking daily vitamin D supplements - which are inexpensive, safe and widely available - proved to be quite helpful." Camargo led both the earlier Boston pilot study and the current investigation, which was performed in collaboration with investigators from the Health Sciences University of Mongolia.

A chronic inflammatory disorder of the skin, atopic dermatitis is uncomfortable and makes patients more vulnerable to bacterial infection. Symptoms of the disorder - most commonly seen in children - often worsen during wintertime. While controlled administration of ultraviolet light, which can stimulate the production of vitamin D in the skin, is a common treatment for severe atopic dermatitis, the possibility that vitamin D deficiency contributes to the seasonal worsening of symptoms had received little consideration prior to the Boston study. That investigation involved only 11 children but provided preliminary support for the hypothesis.

The current study, conducted in collaboration with the National Dermatology Center in Mongolia, enrolled 107 children, ages 2 to 17, from nine outpatient clinics in the capital city of Ulaanbaatar. The participants - all of whom had a history of atopic dermatitis symptoms worsening either during cold weather or around the transition from autumn to winter - were randomly divided into two groups. One group received a daily vitamin D dose of 1000 IU while the other received a placebo - both delivered in odorless, colorless and tasteless drops. Neither the children's parents nor the study investigators knew to which group participants had been assigned.


Standard evaluations of atopic dermatitis symptoms were conducted at the outset of the trial and at the end of the month-long study period, and parents were also asked whether they saw any improvement in their child's condition. At the end of the month, children receiving the vitamin D supplement had an average 29 percent improvement on the primary assessment tool used, compared with 16 percent improvement in the placebo group. Additional assessments - including the report from parents - also showed significantly greater improvement among children receiving vitamin D.

While data gathered at the outset of the study could not determine whether or not participating children were deficient in vitamin D, the authors note that an even larger study of Ulaanbaatar children conducted at the same time found significant vitamin D deficiency in 98 percent of participants, supporting the probability that the children in this study were also deficient. While future studies are needed to assess the value of vitamin D treatment in adults and in children with year-round symptoms, Camargo - a professor of Medicine at Harvard Medical School - says that parents of children with symptoms that worsen in the winter should try a vitamin D supplement for a few weeks when symptoms flare to see if it helps. He encourages parents to discuss this study and their plan with their primary care provider.

 

 

 

Feature

13 November 2014 0 Comments

 

 

 


Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a subsequent new diagnosis of vitamin B12 deficiency, according to a study appearing in the December 11 issue of JAMA.

"Vitamin B12 deficiency is relatively common, especially among older adults; it has potentially serious medical complications if undiagnosed. Left untreated, vitamin B12 deficiency can lead to dementia, neurologic damage, anemia, and other complications, which may be irreversible," according to background information in the article. Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid, which may lead to malabsorption of vitamin B12, and they are among the most commonly used pharmaceuticals in the United States. However, few data exist about any association between long-term exposure to these medications and vitamin B12 deficiency in large population-based studies.

Jameson R. Lam, M.P.H., of Kaiser Permanente, Oakland, Calif., and colleagues evaluated the relationship between the use of acid-suppressing prescription medications and vitamin B12 deficiency within the Kaiser Permanente Northern California population. The researchers identified 25,956 patients having new diagnoses of vitamin B12 deficiency between January 1997 and June 2011 and 184,199 patients without B12 deficiency, and compared their exposure to acid inhibitors as observed via electronic pharmacy, laboratory, and diagnostic databases.

Among patients with a new diagnosis of vitamin B12 deficiency, 3,120 (12.0 percent) were dispensed a 2 or more years' supply of PPIs, 1,087 (4.2 percent) were dispensed a 2 or more years' supply of H2RAs (without any PPI use), and 21,749 (83.8 percent) had not received prescriptions for either PPIs or H2RAs. Among control patients, 13,210 (7.2 percent) were dispensed a 2 or more years' supply of PPIs, 5,897 (3.2 percent) were dispensed a 2 or more years' supply of H2RAs (without any PPI use), and 165,092 (89.6 percent) had not received prescriptions for either PPIs or H2RAs.



The researchers found that the magnitude of the association was stronger in women and younger age groups with more potent acid suppression (PPIs vs. H2RAs), and that the association decreased after discontinuation of use. There was no significant trend with increasing duration of use.

"We cannot completely exclude residual confounding [factors besides the drugs] as an explanation for these findings, but, at minimum, the use of these medications identifies a population at higher risk of B12 deficiency, independent of additional risk factors. These findings do not recommend against acid suppression for persons with clear indications for treatment, but clinicians should exercise appropriate vigilance when prescribing these medications and use the lowest possible effective dose. These findings should inform discussions contrasting the known benefits with the possible risks of using these medications," the authors conclude.

 

 

 

Feature

19 October 2014 0 Comments

 

 

 

Supplementation with omega-3 fatty acids promotes effective immune system response and has ameliorating effects on chronic inflammation (a condition caused by an imbalanced immune system that can lead to multiple serious illnesses over time), according to the most recent study published by the National Center for Biotechnology Information (a division of the U.S. National Institutes of Health) on the effects of omega-3. It is for this reason that omega-3, in addition to playing a crucial role in human growth and brain development, may be highly useful in the prevention and treatment of autoimmune diseases such as rheumatoid arthritis, ulcers, psoriasis, lupus, multiple sclerosis, and migraine.

The polyunsaturated fatty acids omega-3 and omega-6 cannot be synthesized by the body and must therefore be taken in as nutrition. Paradoxically, however, an excess of omega 6 may actually result in greater inflammation. This is why a healthy diet needs to achieve a proper balance between omega-3 and omega-6. Such is not currently the case in most American diets, which typically provide 14 to 25 times more omega 6 fatty acids than omega-3.

Typically standard fish oil supplements only have 30% omega-3 fatty acids and the same amount of saturated and monounsaturated (30% each), making their effectiveness doubtful.  

Supplements such as OmegafortSCC have 85% omega-3 content and are backed by studies that support that the higher the concentration the higher the effectiveness of the omega-3 supplementation on our health.

A single high-potency OmegafortSCC capsule provides amounts of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) which are four times higher than conventional fish-oil capsules.
Source:

Megafort

 

 

 

Feature

01 December 2014 0 Comments

 

 

 

A recent study presented at the Gerontological Society of America's 62nd Annual Scientific Meeting shows that a combination of vitamins and nutriceuticals improves memory and cognitive performance in community-dwelling adults.

A team of researchers at the University of Massachusetts Lowell tested the efficacy of a specially designed formulation on cognitive performance in healthy adults. The nutriceutical formulation includes vitamin B12, folate, vitamin E, S-Adenosyl L-methionine (SAM-e), Acetyl-L-carnitine (ALCAR) and N-acetyl cysteine (NAC).

Study participants were randomly assigned to receive either the nutriceutical formulation or the placebo. Using standardized cognitive tests, the researchers concluded that the nutriceutical formulation can improve cognitive performance in healthy adults.


The standardized cognitive tests assessed for changes for simple memory (Digit-Recall test and CVLT II) and executive function (Trail-making test). The researchers concluded that the nutriceutical formulation enhances cognitive performance in healthy adults based on the statistically significant improvements in their scores. In addition, participants declined to their baseline performance level when the nutriceutical formulation was discontinued and achieved similar improvement following resumption of the nutriceutical formulation. The research team concluded that continued consumption of the nutriceutical formulation is required to maintain the beneficial cognitive effects.

"These findings suggest that people taking the nutriceutical formulation on a regular basis may be able to carry out complex mental tasks more quickly and more efficiently," said Dr. Ruth Remington from the University of Massachusetts Lowell team. "This is very exciting news in the area of cognitive health and shows an approach that healthy adults can take to stay sharp as they age," she continued.

Study participants were adults with no known dementia or clinical memory conditions. This is particularly noteworthy because, while this combination of vitamins and nutriceuticals has demonstrated effectiveness for cognitive health in patients diagnosed with Alzheimer's disease or dementia, this study shows a positive effect in individuals with no known memory problems.

 

 

 

Feature

09 November 2014 0 Comments

 

 

 


A Texas AgriLife Research scientist and fellow researchers have discovered that arginine, an amino acid, reduces fat mass in diet-induced obese rats and could help fight human obesity.

"Given the current epidemic of obesity in the U.S. and worldwide, our finding is very important," said Dr. Guoyao Wu, an AgriLife Research animal nutritionist in College Station and Senior Faculty Fellow in the department of animal science at Texas A&M University.

The research found dietary arginine supplementation shifts nutrient partitioning to promote skeletal-muscle gain, according to the researchers. The findings were published recently in the Journal of Nutrition (http://jn.nutrition.org).

In laboratory experiments, rats were fed both low-and high-fat diets. They found that arginine supplementation for a 12-week period decreased the body fat gains of low-fat and high-fat fed rats by 65 percent and 63 percent, respectively. The long-term arginine treatment did not have any adverse effects on either group.

"This finding could be directly translated into fighting human obesity," Wu said. "At this time, arginine has not been incorporated into our food (but could in the future)."

Arginine-rich foods include seafood, watermelon juice, nuts, seeds, algae, meats, rice protein concentrate and soy protein isolate, he said.

The research suggests that arginine may increase lean tissue growth. In pigs, it was found that dietary arginine supplementation reduced fat accretion (growth) but increased muscle gain in growing/finishing pigs without affecting body weight.

Another important observation according to the research was that dietary arginine reduced serum concentrations of branched-chain amino acids.

"This metabolic change is likely beneficial because elevated concentrations of branched-chain amino acids may lead to insulin resistance in obesity. Additionally, arginine can stimulate muscle protein synthesis, a biochemical process that requires large amounts of energy," Wu said. "Thus, dietary energy would be utilized for lean tissue rather than fat gain."
Source:

http://www.tamu.edu/

 

 

 

 

Feature

19 October 2014 0 Comments

 

Supplementation with omega-3 fatty acids promotes effective immune system response and has ameliorating effects on chronic inflammation (a condition caused by an imbalanced immune system that can lead to multiple serious illnesses over time), according to the most recent study published by the National Center for Biotechnology Information (a division of the U.S. National Institutes of Health) on the effects of omega-3. It is for this reason that omega-3, in addition to playing a crucial role in human growth and brain development, may be highly useful in the prevention and treatment of autoimmune diseases such as rheumatoid arthritis, ulcers, psoriasis, lupus, multiple sclerosis, and migraine.

The polyunsaturated fatty acids omega-3 and omega-6 cannot be synthesized by the body and must therefore be taken in as nutrition. Paradoxically, however, an excess of omega 6 may actually result in greater inflammation. This is why a healthy diet needs to achieve a proper balance between omega-3 and omega-6. Such is not currently the case in most American diets, which typically provide 14 to 25 times more omega 6 fatty acids than omega-3.

Typically standard fish oil supplements only have 30% omega-3 fatty acids and the same amount of saturated and monounsaturated (30% each), making their effectiveness doubtful.  

Supplements such as OmegafortSCC have 85% omega-3 content and are backed by studies that support that the higher the concentration the higher the effectiveness of the omega-3 supplementation on our health.

A single high-potency OmegafortSCC capsule provides amounts of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) which are four times higher than conventional fish-oil capsules.
Source:

Megafort

 

 

 

Feature

26 November 2014 0 Comments

 

 

 

Tiny RNAs shed by tumours can transform healthy cells into cancerous ones.

When a cancer cell throws out its trash, it can turn healthy neighbours into fellow tumour cells, researchers have found.

Many cells, including cancerous ones, shed thousands of tiny membrane-bound vesicles called exosomes that contain proteins, DNA and RNA. The process is thought to be a waste-management system, but it may also facilitate cell-to-cell communication: some of these vesicles can then merge with other cells and dump their payload inside.

In a study published online on 23 October in Cancer Cell1, researchers show that when human breast-cancer exosomes can cause tumours when mixed with normal cells then injected into mice. The results could pave the way to finding markers to monitor the progression of cancer, and possibly even point to targets for therapies.

“It’s amazing — these vesicles were considered garbage cans,” says Khalid Al-Nedawi, a cancer researcher at McMaster University in Hamilton, Canada. “This paper really brings us closer to harnessing the potential of these tiny vesicles.”

Previous studies had shown that cancer cells crank out more exosomes than normal cells2. Cancer researcher Raghu Kalluri of the MD Anderson Cancer Center in Houston, Texas, and his colleagues therefore decided to look into how the two types of exosome might differ. They isolated exosomes from cells grown in culture and found that, unlike normal exosomes, those from cancer cells contained the building blocks required to produce the short fragments of RNA called microRNA that can shut off the expression of target genes.

Exposure to the cancer exosomes altered gene expression in the normal cells. Those cells then caused tumours when injected into mice. Exosomes from normal cells did not yield tumours, however, and tumour growth was reduced in cells exposed to cancer exosomes in which the microRNA-producing molecular machinery had been disabled.

The team also collected exosomes from the blood of 8 healthy individuals and 11 people with breast cancer. Five of the 11 exosome samples from the patients induced tumour growth when mixed with normal cells and injected into mice; none of the exosome samples from healthy people did so.

It is unclear how far exosomes can travel in the body, says Kalluri, but the fact that the team could isolate them from blood suggests that they could be quite mobile. And even if their effect is only local, they could still make nearby cancer cells more aggressive, or transform healthy cells into cancerous ones, he says.


 

 

 

Feature

02 November 2014 0 Comments

 

 

 

English

Reported by department of technology & communication of YaghootRooyan International Holding Group, the second festival & national exhibition of herbal medicine, natural products & Iran’s traditional medicine was held on the 29th September till 2nd October in this year.
This festival & exhibition which was held by science & technology development staff of herbal & traditional medicine related to deputy science & technology of president’s office, included 14 fundamental in this field along with 4 educational workshops.
The main range of audiences of this festival, were public &private companies, in particular private & public knowledge base institutes, researchers, industrialists, entrepreneurs & investors who wish to invest in this area. Furthermore physicians, producers of herbal products & medicine, inventors related to the field, students & professionals were present in the exhibition.
In this fair which was held by presence of Dr. Jahangiri, first deputy of president, Dr. Sattari, science & technology deputy of president & Mahmoud Hojati, agriculture minister, one of the fundamental was introducing herbal products & food supplements. In this regard 5 new products of SepidTeb pharmaceutical company were launched.
SepidTeb which is one of the active knowledge base companies in the country, not only promoted&culturized appropriate use of herbal supplements, but also took the opportunity to make agreements for cooperation in the development of this industry, through exchange of ideas, communication and consultation with manufacturers & entrepreneurs in this area.
It is noteworthy, at this festival SepidTeb pharmaceutical company was chosen as one of selected knowledge base companies in pharmaceutical field.one of the most important factors for this to happen is a research & development center belongs to this company which by considering market demand in the country, could take a significant step in the production of new products & upgrade it’s previous.
Dr.SeyedHosseinEtemadi, founder of YaghootRooyan Int’l Holding Group said that quick commercialization process, creative& innovative human resources & also keeping pace with the world’s latest technology are the other factors for success of SepidTeb pharmaceutical company.


French

Dévoilement des 5 produits de l'industriepharmaceutiqueSepidTebdans la deuxièmeédition du Festival de la médecinetraditionnelleet les plantesmédicinales.
Selon le département de la technologieet de la communication possession international YaghoutRoyan, le deuxième festival national et l'exposition de plantesmédicinales, les produits de la médecinenaturelle et la médecinetraditionnelle 07-10 mehr de l'année a eu lieu.
Le festival et de l'exposition en coursd'élaboration par le Comité de la science et de la technologie des plantesmédicinales et vice-président de la médecinetraditionnelleassocié de la science et de la technologie a eu lieu .was Composé de 14 selon le domainefondamental et 4 ateliers.
Qu'est-ceque les contacts d'origine de cette festival publiéparticulaireetCamarades, les institutions Governali, les institutions privéesfondéessur les connaissances, les chercheurs, les propriétairesindustriels, entrepreneurs, Les investisseurs qui souhaitentinvestirdanscettepartie.
Dansce festival aussi des médecins, des fabricants de produits à base de plantes et les médicaments, les inventeurs et les technologies relatives à la partie, les étudiants et les professionnelsparicipavano.
Vouset le joint avec le docteurJahangiri, participer à ce festival, premier vice-président. ProfesseurSattari, vice-président de la technologie.également Dr. Mahmoud Janatti, ministre de l'AgricultureL'un des principauxsujetsétaientl'introduction de produits à base de plantes et complémentsalimentaires à cetégard, a étédévoilé 5 nouveaux produitspharmaceutiquesSepidTeb.
PharmacieSepidTebest un des activistesbaséssur la connaissanceontprésentéleurs nouveaux produits à la foire, Avec saprésence au festival, en plus de promouvoir la culture et la bonne utilisation des suppléments, herbes, Grâce à l'échanged'idéesconversation avec les producteurs et les autres entrepreneurs danscesecteur. Accord de coopération pour le développement du secteuratteint.
Ilest à noter commerce SepidTebdans le festival commel'une des sociétés leader dans la base de connaissancespharmaceutiquea étéchoisi.commel'un des facteurs les plus importantsdans la prise de cetévénement un centre de recherche et développement.
en tenant compte du marché et de leurs contacts dans le pays peutêtreuneétapeimportantedans la production de nouveaux produits et l'amélioration du choix de produitsprecedent.


Italian

Scoprimento di 5 prodottidellaaziendafarmaceuticaSepidTebnel secondo Festival dellamedicinatradizionale e piantimedicinali.
Secondo ildipartimento di tecnologia e comunicazionepossessointernazionaleYaghoutRoyan, il secondo festival nazionale e l'esposizionedellepiantemedicinale, prodotti di medicinanaturale e medicinatradizionale dal 07 al 10 mehr del quest'annosi è tenuto.
Il Festival e mostraEssendosviluppato dal ComitatoScienza e dellaTecnologia di piantemedicinali e medicinatradizionaleassociate di vice presidentedellascienza e dellatecnologiasi è tenuta .era Costituito da 14 basatafondamentalesul campo e 4 officine.
Ciòchecontattioriginali di questo festival hannopubblicato e particolato I compagni, istitutigovernali, istituti private base sulconoscenza, ricercatori, Proprietari industrial, imprenditori, Gliinvestitorichedesideranoinvestire in questa parte.
In questo festival anchemedici, I fabbricanti di prodottisul base di pianti e farmaci, Inventori e tecnologieriguardantila parte, Studenti e professionistiparicipavano.
Si e tenuta con DottoreJahangiriparticipavano in questofestival,primovice di presidente. ProfessoreSattari, Vice Presidente di tecnologia.anchedottore Mahmoud Janatti, Ministrodell'Agricoltura. Uno degliargomentiprincipali, eranol'introduzione di prodottierboristici e integratorialimentari A questoproposito, è statosvelatoi 5 nuoviprodottifarmaceuticiSepidTeb.
FarmaciaSepidTeb è un attivistibasatisullaconoscenzaintrodottoiloronuoviprodotti in fiera, Con la suapresenza al festival, oltre a promuovere la cultura e ilcorrettouso di integratori a base dell, erbe, Attraverso lo scambio di idee, conersazione con I produttori e glialtriimprenditori di questosettore. Accordo di cooperazione per lo sviluppodelsettoreraggiunta.
Si segnalacommercioSepidTebnel festival Come unadelleaziende leader nella parte della base di conoscenzefarmaceutico è statoscelto come unodeifattoripiùimportantinellarealizzazione di questoeventoavere un centro di ricerca e sviluppo, tenendoconto del mercatoedilorocontattinelpaesepuoavere un passoimportantenellaproduzione di nuoviprodotti e miglioramentiallescelte di prodotti precedent.
ProfessoreSeyedHosseinEtemadi, ilfondatore di international holding YaghoutRouyan, processo di commercializzazionerapidamene,avereImpiegaticreativi e innovative anchetenereilpasso con le ultimetecnologie del mondosaAltrifattori di successi di SepidTeb

 

 

 

 

 

 

Feature

08 October 2014 0 Comments

 

 

 

The intake of preformed vitamin A from animal products is not sufficient in parts of the population in the U.S., Europe and Asia. The vitamin A precursor beta-carotene therefore has an important function in providing for an adequate supply of total vitamin A, international carotenoid experts state in a recently published consensus answer. An appropriate intake of beta-carotene from diet, fortified foods and/or dietary supplements could safely compensate for the lack of vitamin A. However, based on recent data from national nutrition surveys, the dietary intake of beta-carotene from food sources is insufficient in a substantial part of the population. Moreover, many people may suffer from a reduced ability to produce sufficient amounts of vitamin A from beta-carotene due to genetic variations. Consequently, experts are calling for guarantees that recommended intakes of beta-carotene are met or, if the current recommended dietary amounts for vitamin A are not met, that beta-carotene intake should be increased. This would ensure that at least 95% of the population consume an adequate amount of total vitamin A.

Leading experts in the fields of medical and nutritional science from the U.S., Europe and Asia met at a Consensus Conference to elucidate the current knowledge with respect to physiological function, supply situation, and intake recommendations of beta-carotene. The experts reached an agreement formulated in a consensus answer published recently in The Journal of Nutrition.

Vitamin A and beta-carotene intake often critically low

Vitamin A is essential for normal growth and development, immune system, vision and other functions in the human body. In situations such as pregnancy and lactation, vitamin A plays a particularly important role in the healthy development of the child, and an increase in vitamin A (retinol) intake has been recommended under these conditions. However, surveys undertaken in several countries suggest that vitamin A intake patterns vary considerably across Europe, the U.S. and Asia. National survey data show that the intake of preformed vitamin A (retinol) - as such only present in animal products (especially liver) - is often critically low and does not meet the recommendations. Groups especially at risk of inadequate vitamin A supply are pregnant and lactating women, newborns, children with frequent infections, young women, the elderly and people who avoid animal-derived foods.

National Consumption Surveys indicate that beta-carotene - as a vitamin A precursor - contributes significantly to balance inadequate vitamin A supply in large parts of the population. However, European, U.S. and Asian studies show that a substantial part of the population does not reach the recommendation for beta-carotene necessary to compensate the low vitamin A intake from sources containing preformed vitamin A in the regular diet.

Recent evidence has shown that suboptimal levels of vitamin A and beta-carotene, even well above those causing clinical deficiency syndromes, can be risk factors for chronic diseases.


Vitamin A deficiency through beta-carotene-dependent gene variants

The bioavailability of beta-carotene is influenced by numerous factors. In addition to food-related factors, such as food matrix, food processing, dosage, fat in the meal, and dietary fibers, the bioavailability of beta-carotene depends on consumer-related factors including vitamin A status, gut integrity and genetic variations.

Recent research on female subjects has shown that almost 50% of the population have a genetic variation which reduces their ability to produce sufficient amounts of vitamin A from beta-carotene. Studies indicate that younger women carrying the genetic variation are at particular risk as they tend to eat not enough vitamin A-rich foods relying heavily on the beta-carotene form of the nutrient.

Experts call for increase of beta-carotene intake recommendations

It is apparent from a variety of studies that beta-carotene is essential in striving for the recommended vitamin A intake. In cases of a poor vitamin A status due to low intake of preformed vitamin A, the current recommendations for beta-carotene in the range of 2-4 mg per day still might not sufficiently correct the individual vitamin A status.

In their consensus answer the experts conclude that ignoring inter-individual differences in the ability to convert beta-carotene to vitamin A and assuming that intakes of preformed retinol do not change, it should be ensured that the current recommended intakes of beta-carotene are attained. At the same time, people with an inadequate intake of preformed vitamin A should increase consumption to 7 mg per day, based on a realistic and now in the scientific community generally accepted conversion efficiency of 1:12 (12 milligrams of beta-carotene are necessary to form one milligram of vitamin A). This should ensure that at least 95% of the population meet the recommended intakes of total vitamin A.

Individuals with reduced conversion efficiencies due to a genetic variability in beta-carotene metabolism might need to increase their daily intakes even further. This is currently being investigated.

No functional difference between natural and synthetic beta-carotene

According to the experts, there is no difference in function between naturally occurring and chemically synthesized beta-carotene, whereas there is a difference in bioavailability from different food sources. In humans, the predominant molecular type is 'all-trans beta-carotene', used for most dietary supplements and fortified foods; it is absorbed preferentially compared to other forms.

As the general population is not obtaining sufficient beta-carotene from fruit and vegetables, foods fortified or colored with beta-carotene and dietary supplements can be important contributors to the daily supply of vitamin A.
Source:

CommuniPoweR Wolfgang Zoell

 

 

 

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20 November 2014 0 Comments

 

 

 

 

 

 

 



Today's Scientific Program of the 2010 American Academy of Ophthalmology (AAO) - Middle East-Africa Council of Ophthalmology (MEACO) Joint Meeting includes a report on beta carotene's ability to improve vision in people with certain incurable retinal diseases. The AAO-MEACO meeting-the world's largest, most comprehensive ophthalmic education conference-is in session October 16 through 19 at McCormick Place, Chicago.

cis Beta-Carotene Mat Boost Vision in Some Patients with Incurable Retinal Disease Retinitis pigmentosa (RP) is a cluster of hereditary disorders of the retina (the light-sensitive tissue at the back of the eye) that can result in incurable blindness. RP usually begins with night blindness in childhood, then loss of peripheral (side) vision leading to tunnel vision, and ultimately blindness. Since a specific form of the nutrient beta carotene, 9-cis, has been effective against one type of night blindness, researchers decided to test its effects in RP patients. One third of the 29 participating patients showed improved visual function while taking the prescribed oral dose for 90 days, but the other two-thirds showed no effect.

"We recommend repeating the study with patients with the genetic forms of RP that would be most likely to respond to oral beta carotene," said Dr. Rotensteich. "We know its positive effect is associated with retinoid cycle defect, which is involved in some but not all forms of RP. Also, future research should look for the optimal beta carotene dosage," he added.

 

 

 

 

 

 

 

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02 November 2014 0 Comments

 Reported by department of technology & communication of YaghootRooyan International Holding Group, the second festival & national exhibition of herbal medicine, natural products & Iran’s traditional medicine was held on the 29th September till 2nd October in this year.
This festival & exhibition which was held by science & technology development staff of herbal & traditional medicine related to deputy science & technology of president’s office, included 14 fundamental in this field along with 4 educational workshops.
The main range of audiences of this festival, were public &private companies, in particular private & public knowledge base institutes, researchers, industrialists, entrepreneurs & investors who wish to invest in this area. Furthermore physicians, producers of herbal products & medicine, inventors related to the field, students & professionals were present in the exhibition.
In this fair which was held by presence of Dr. Jahangiri, first deputy of president, Dr. Sattari, science & technology deputy of president & Mahmoud Hojati, agriculture minister, one of the fundamental was introducing herbal products & food supplements. In this regard 5 new products of SepidTeb pharmaceutical company were launched.
SepidTeb which is one of the active knowledge base companies in the country, not only promoted&culturized appropriate use of herbal supplements, but also took the opportunity to make agreements for cooperation in the development of this industry, through exchange of ideas, communication and consultation with manufacturers & entrepreneurs in this area.
It is noteworthy, at this festival SepidTeb pharmaceutical company was chosen as one of selected knowledge base companies in pharmaceutical field.one of the most important factors for this to happen is a research & development center belongs to this company which by considering market demand in the country, could take a significant step in the production of new products & upgrade it’s previous.
Dr.SeyedHosseinEtemadi, founder of YaghootRooyan Int’l Holding Group said that quick commercialization process, creative& innovative human resources & also keeping pace with the world’s latest technology are the other factors for success of SepidTeb pharmaceutical company.

 

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01 October 2014 0 Comments

 

 

 


New research has shown for the first time that omega-3 in fish oil could "substantially and significantly" reduce the signs and symptoms of osteoarthritis.

According to the University of Bristol study, funded by Arthritis Research UK and published in the journal Osteoarthritis and Cartilage, omega-3-rich diets fed to guinea pigs, which naturally develop osteoarthritis, reduced disease by 50 per cent compared to a standard diet.

The research is a major step forward in showing that omega-3 fatty acids, either sourced from fish oil or flax oil, may help to slow down the progression of osteoarthritis, or even prevent it occurring, confirming anecdotal reports and "old wives' tales" about the benefits of fish oil for joint health.

Lead researcher Dr John Tarlton, from the Matrix Biology Research group at the University of Bristol's School of Veterinary Sciences, said classic early signs of the condition, such as the degradation of collagen in cartilage and the loss of molecules that give it shock-absorbing properties, were both reduced with omega-3.

"Furthermore, there was strong evidence that omega-3 influences the biochemistry of the disease, and therefore not only helps prevent disease, but also slows its progression, potentially controlling established osteoarthritis," he said.

Dr Tarlton added: "The only way of being certain that the effects of omega-3 are as applicable to humans as demonstrated in guinea pigs is to apply omega-3 to humans. However, osteoarthritis in guinea pigs is perhaps the most appropriate model for spontaneous, naturally occurring osteoarthritis, and all of the evidence supports the use of omega-3 in human disease."


Medical research director of Arthritis Research UK, Professor Alan Silman, said: "The possibility that omega-3 fatty acids could prevent osteoarthritis from developing has been a tantalising one. Some limited, previous research in dogs has suggested that we were a long way away from understanding the potential use in humans. However, this current research in guinea pigs is exciting as it brings us closer to understanding how omega-3 might fundamentally interfere with the osteoarthritis process, and that it could potentially be taken as a treatment."

On the back of the results of his study, Dr Tarlton said that following government guidelines on dietary intake of omega-3 fatty acids could be effective in reducing the burden of osteoarthritis. Fish oil is far more effective than the flax oil based supplement, but for vegetarians flax oil remains a viable alternative.

"Most diets in the developed world are lacking in omega-3, with modern diets having up to 30 times too much omega-6 and too little omega-3. Taking omega-3 will help redress this imbalance and may positively contribute to a range of other health problems such as heart disease and colitis."

Further studies are needed to determine the influence of omega-3 fatty acids on established disease in guinea pigs, and to confirm the effects in human osteoarthritis, said Dr Tarlton.
Source:

University of Bristol

 

 

 

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