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McGill researchers have shown that melatonin supplements may make bones stronger in old rats. This suggests a possible avenue for the prevention of osteoporosis. Bones are built up by certain cells known as osteoblasts during the daytime and broken down by others (osteoclasts) at night. As we age, we sleep less, and so the cells that break down the bones are more active.  By giving old rats melatonin supplements to regulate their circadian rhythms, the McGill researchers have been able to make their bones denser, less brittle and more flexible. Next step is to explore whether melatonin supplements prevent bone breakdown or can actually repair damage.

Research on elderly rats suggests possible avenue for prevention of osteoporosis

Faleh Tamimi, a professor in McGill's School of Dentistry, is the leader of a research team that has just discovered that melatonin supplements make bones stronger in elderly rats and therefore, potentially, in elderly humans too. "Old rats are tedious to work with because they get sick a lot and that means they also cost a lot more. But if you're interested in diseases like osteoporosis, they're an essential part of the process."

Dem bones, dem bones, dem dry bones - sleep and bone regulation

The process of bone breakdown and buildup is affected by our circadian rhythms. The cells which break down our bones (known as osteoclasts) are more active at night, while those responsible for bone formation (osteoblasts) are more active during daylight hours. "As we age, we sleep less well, which means that the osteoclasts are more active," says Tamimi. "This tends to speed up the process of bone breakdown."

It is already well established that melatonin plays a role in regulating our body clocks and can potentially help us sleep better. So the researchers suspected that a melatonin supplement would help regulate the circadian rhythms of the elderly rats, thus reducing the activity of the osteoclasts and slowing down the process of bone breakdown. And that is exactly what they found.



The researchers found that there was a significant increase in both bone volume and density among the rats that had received melatonin supplements. As a result, it took much more force to break the bones of rats that had taken the melatonin supplements, a finding that suggests to the researchers that melatonin may prove a useful tool in combatting osteoporosis.

For Tamimi and his colleagues the next big question is whether melatonin is preventing or actually reversing the process of bone breakdown. "Until there is more research as well as clinical trials to determine how exactly the melatonin is working, we can't recommend that people with osteoporosis go ahead and simply take melatonin supplements," says Tamimi. "I am applying for funding to pursue the research and we hope to have answers soon."

 

 

 

 

 

 


Despite past safety concerns, the antioxidant supplement beta-carotene, is safe to use during radiation therapy treatments for prostate cancer and does not increase the risk of prostate cancer death or metastases, according to a study in the May issue of the International Journal of Radiation Oncology•Biology•Physics, the official scientific journal of the American Society for Radiation Oncology (ASTRO).

The use of vitamin supplements and antioxidants is common, but the safety of using antioxidant supplements during radiation treatments for prostate cancer is controversial. Radiation therapy relies on the pro-oxidant effects of DNA, which involves damaging tumor cells while leaving normal cells unharmed. However, some scientists have suggested that supplemental antioxidants may weaken the oxidizing effects of radiation and potentially lead to cancer recurrence.

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In the largest study to date of its kind, researchers followed 383 prostate cancer patients who were randomized to receive beta-carotene or placebo to determine if antioxidants could potentially counteract the pro-oxidant effects of radiation therapy and increase a patient's risk of death or metastases. The primary endpoint was prostate cancer death or bone metastases.

Researchers found no significant differences in lethal outcomes among the patients who took the antioxidant beta-carotene versus those who did not.

"This study shows that antioxidant supplementation with beta-carotene during radiation therapy does not appear to detract from the benefit of radiation therapy." Danielle Margalit, MD, MPH, lead author of the study and a radiation oncologist at the Dana-Farber Cancer Institute in Boston, said. "It also suggests that patients may continue to eat a well-balanced diet that contains foods with natural sources of antioxidants at the recommended daily amount.

 

 

 

 

 

 


Walking through the supplement aisle can make you feel pretty confident. Promises like “fat loss,” “muscle gain,” and “reduced aging” plaster nearly every bottle and container. And with more than 29,000 dietary supplements to choose from, there’s no wonder you feel uncertain about which ones are more show than substance. Here are top supplements—sensational marketing claims sold separately.

1. Fish Oil

Fish oil is known for delivering omega-3’s, essential fats that our bodies can’t make on our own so must get them from our diet. Even if you eat fish one to two times per week, you won’t be taking in enough omega-3’s to meet your body’s needs. By taking a high quality fish oil, you can reduce triglycerides, lower your risk of heart disease, protect your brain health, and potentially lower your risk of diabetes. Omega-3’s may even help with losing body fat. When choosing a supplement, pay seeks brands that deliver a minimum of 2 g EPA and DHA (two of the three acids in omega-3s) daily.

2. Vitamin D

Plenty of data has suggested that the majority of Americans have less than optimal levels of Vitamin D. That’s not surprising – the nutrient is tough to get from food (though canned salmon, milk, and sardines are all good sources), and the only other method is sunlight. Some people live in areas with less sunlight, and cannot make sufficient amounts of this vitamin, and even when you are outside, most people are covered with clothing and/or suntan lotion. Most experts agree that supplementing with at least 1000 IU’s daily is a good start.

3. Whey Protein

Whey protein is not an essential supplement, but it is a good one to have on hand. Because whey is high in branched-chain amino acids, it can aid recovery from exercise. More importantly, whey protein is a quick, convenient source of quality calories.

4. Greens Products

While not a replacement for fruits and vegetables, Greens products (fruit and vegetable concentrates) are a good “insurance” policy if your produce consumption is lower than idea. Less than 6% of men and 9% of women aged 5 to 34 consume the recommended minimum of five servings of fruits and vegetables each day. Greens can help fill this void. They’re especially handy when real produce is hard to come by, like during times of heavy travel.

5. Probiotics

Here’s the deal -- there are millions of different strains of bacteria in our guts. Some are good. Others, not so much. The bacteria in your gut can influence your overall health, digestion and immune system. Probiotics can help replenish and nourish your internal supply of good bacteria, sometimes leading to less gas, bloating, and abdominal pain. Aim for a product from a trusted brand that lists at least 3 billion organisms per serving. Keep it refrigerated after opening to protect those organisms.

6. Turmeric (Curcumin)

Turmeric is a spice commonly used in Indian dishes, and a key component in the spice is curcumin. Hundreds have studies have suggested that curcumin possesses a wide range of beneficial health properties, including anti cancer, anti viral, anti arthritic and anti inflammatory properties. The nutrient’s very strong anti inflammatory actions are seen as one of the primary drivers of these benefits.

7. Cinnamon

Another powerful spice, cinnamon has one of the highest antioxidant levels of any of the spices. Several studies have shown that cinnamon may improve insulin sensitivity, which improves utilization of carbohydrates and leads to better blood sugar control. Sprinkle it in shakes, on oats, yogurt, cottage cheese or wherever you’d enjoy the added flavor. Or if you want the assurance of getting a specific dose, you can choose a supplement. Studies have shown that 1g daily (about 1/2 teaspoons) is sufficient.

8. Psyillium

Psyillium is a soluble fiber that can help lower cholesterol and regulate blood sugar in people who have diabetes. If you choose to supplement, start with small doses and build over time.

9. Creatine

Creatine is one of the most extensively studied nutritional supplements, both in clinical research and by real-life athletes, and to date most findings indicate one thing: Creatine works. The supplement may enhance muscle function during high-intensity exercise, and cause muscle hypertrophy, likely due to increased water retention by muscle cells, although some data suggest there may be gains in muscle fiber diameter as well. Vegetarians may have a greater response to supplementation because of their limited intake of dietary creatine. Creatine supplementation under supervision, 3-5g per day, can help improve strength or speed, or help you add on weight.

10. Beta Alanine

β-Alanine supplements have garnered interest over the last several years as several research investigations have linked its use to performance improvements. Some clinical research shows that taking beta-alanine improves some measures of physical performance, especially during high-intensity exercise and strength training. Beta-alanine is used, under supervision, for improving athletic performance and exercise capacity, building lean muscle mass, and improving physical functioning in the elderly.

11. Glucosamine

Glucosamine is found naturally in the body, particularly in the cartilage: it is one of the building blocks of cartilage and is also found in the fluid that lubricates the body's joints. Glucosamine's job in the body is to generate cartilage production and repair. It can also be manufactured and sold in supplement form -- this type of glucosamine often comes from animal cartilage.

12. Green Tea

Green tea contains high levels of polyphenols, a type of antioxidant that helps combat dangerous free radicals, which can damage cells and DNA. Polyphenols may also be able to prevent inflammation and swelling. The antioxidants in green tea supplements may help protect the heart and blood vessels.

 

 

 

References

1- Journal of the American College of Nutrition: Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

2- Journal of the American Medical Association: Effects of Omega-3 Fatty Acids on Cancer Risk

3- SpringerLink: Omega-3 Fatty Acids in Psychiatry: A Review

4- "International Journal of Sport Nutrition and Exercise Metabolism"; Effect of Creatine Supplementation and Resistance-Exercise Training on Muscle Insulin-like Growth Factor in Young Adults; D.G. Burke et al.; August 2008

5- "European Journal of Applied Physiology"; The Effects of Creatine Supplementation on Muscular Performance and Body Composition Responses to Short-Term Resistance Training Overeaching; J.S. Volek et al.; May 2004

6- "International Journal of Sport Nutrition and Exercise Metabolism"; Effect of Creatine Supplementation on Body Composition and Performance: A Meta-Analysis; J.D. Branch; June 2003

7- "Molecular and Cellular Biochemistry"; Long-Term Creatine Supplementation Does Not Significantly Affect Clinical Markers of Health in Athletes; R.B. Kreider et al.; February 2003

8- MayoClinic.com; Is it Important to Include Probiotics in a Healthy Diet?; Katherine Zeratsky; April 2010

9- "The Probiotics Revolution: The Definitive Guide to Safe, Natural Health Solutions Using Probiotic and Prebiotic Foods and Supplements"; Gary B. Huffnagle and Sarah Wernick; June 2008

10- Office of Dietary Supplements: Calcium

11- Office of Dietary Supplements: Vitamin D

12- MayoClinic.com; What Are Prebiotics? How Are They Different From Probiotics, and What Health Benefits do They Offer?; Katherine Zeratsky; October 2009

13- Harvard Health Publications: Fish and Fish Oil: Good For Most Folks but Not For ALL

 

 

 

Feature

 

 

 


Death and serious complications more likely in patients with vitamin D deficiency, study suggests
Patients with low blood levels of vitamin D are at increased risk of death and serious complications after noncardiac surgery, suggests a study in Anesthesia & Analgesia.

"Vitamin D concentrations were associated with a composite of in-hospital death, serious infections, and serious cardiovascular events," according to the new research by Dr Alparslan Turan and colleagues of the Cleveland Clinic. They believe their results warrant further study to see if giving vitamin D supplementation before surgery can reduce the risk of these adverse outcomes.

Lower Vitamin D Levels Linked to Higher Surgical Risk

The researchers analyzed the relationship between vitamin D level and surgical outcomes in approximately 3,500 patients who underwent operations other than heart surgery between 2005 and 2011. Only patients who had available data on vitamin D levels around the time of surgery-from three months before to one month afterward-were included in the study.

The concentration of vitamin D (specifically, 25-hydroxyvitamin D) in blood samples was analyzed as a risk factor for death, cardiovascular events, or serious infections while in the hospital. The analysis included adjustment for other factors such as demographic characteristics, medical conditions, and type and duration of surgery.

Most patients did not meet the recommended 25-hydroxyvitamin D concentration of greater than 30 nanograms per milliliter (ng/mL). The median vitamin D level was 23.5 ng/mL-more than 60 percent of patients were in the range of vitamin D insufficiency (10 to 30 ng/mL). Nearly 20 percent had vitamin D deficiency (less than 10 ng/mL).

"Higher vitamin D concentrations were associated with decreased odds of in-hospital mortality/morbidity," the researchers write. For each 5 ng/mL increase in 25-hydroxyvitamin D level, the combined risk of death, cardiovascular events, or serious infections decreased by seven percent.


Further Study Needed to Determine Cause and Effect

"Vitamin D deficiency is a global health problem," according to Dr Turan and coauthors. In addition to protective cardiovascular and neurological effects, vitamin D plays an important role in the immune system.

The high rates of vitamin D insufficiency and deficiency in the surgical patients studied are consistent with previous findings in the general population. In recent years, studies have suggested that vitamin D levels may affect a wide range of health outcomes.

Patients undergoing surgery are at risk of cardiovascular and infectious complications, both of which may be aggravated by vitamin D deficiency. Previous studies found no increased risk of adverse outcomes related to vitamin D levels in patients undergoing cardiac surgery. It may be that the tissue injury and inflammation associated with heart surgery overwhelms any potential protective effect of vitamin D.

However, Dr Turan and colleagues note that their study had some important limitations of their study-especially the fact that it included only patients who had recent measurements of vitamin D levels. They may represent a less-healthy group, introducing a potential source of selection bias.

The study can't determine whether there is any cause-and-effect relationship between vitamin D levels and the risk of adverse outcomes. Dr Turan and colleagues suggest a formal randomized trial to evaluate whether preoperative vitamin D supplementation can reduce the risk of serious complications and death after surgery.

 

 

 

سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است ..

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لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

- محمد دالوند

سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

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سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است .

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Feature

 

 

 

A new study shows that vitamin B12 may protect against Alzheimer's disease, adding more evidence to the scientific debate about whether the vitamin is effective in reducing the risk of memory loss. The research will be published in the October 19, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology.

"Our findings show the need for further research on the role of vitamin B12 as a marker for identifying people who are at increased risk of Alzheimer's disease," said study author Babak Hooshmand, MD, MSc, with Karolinska Institutet in Stockholm, Sweden. "Low levels of vitamin B12 are surprisingly common in the elderly. However, the few studies that have investigated the usefulness of vitamin B12 supplements to reduce the risk of memory loss have had mixed results."

For the seven-year study, researchers took blood samples from 271 Finnish people age 65 to 79 who did not have dementia at the start of the study. During that time, 17 people developed Alzheimer's disease. Blood samples were tested for levels for homocysteine, an amino acid associated with vitamin B12, and for levels of the active portion of the vitamin, called holotranscobalamin. Too much homocysteine in the blood has been linked to negative effects on the brain, such as stroke. However, higher levels of vitamin B12 can lower homocysteine.

The study found that for each micromolar increase in the concentration of homocysteine, the risk of Alzheimer's disease increased by 16 percent, whereas each picomolar increase in concentration of the active form of vitamin B12 reduced risk by two percent. The results stayed the same after taking into account other factors, such as age, gender, education, smoking status, blood pressure and body mass index. The addition of folate did not appear to raise or lower the risk of Alzheimer's disease.

"More research is needed to confirm these findings before vitamin B12 should be used solely as a supplement to help protect memory," said Hooshmand.

Vitamin B12 can be found in fish, poultry and other meat products.

 

 

 

 

 

 

A study conducted in more than 100 Mongolian schoolchildren found that daily treatment with a vitamin D supplement significantly reduced the symptoms of winter-related atopic dermatitis, a type of eczema. Led by a Massachusetts General Hospital (MGH) physician, the report in the October issue of the Journal of Allergy and Clinical Immunology supports the results of a preliminary study that showed similar results in a small group of children in Boston.

"While we don't know the exact proportion of patients with atopic dermatitis whose symptoms worsen in the winter, the problem is common," says Carlos Camargo, MD, DrPH, MGH Department of Emergency Medicine. "In this large group of patients, who probably had low levels of vitamin D, taking daily vitamin D supplements - which are inexpensive, safe and widely available - proved to be quite helpful." Camargo led both the earlier Boston pilot study and the current investigation, which was performed in collaboration with investigators from the Health Sciences University of Mongolia.

A chronic inflammatory disorder of the skin, atopic dermatitis is uncomfortable and makes patients more vulnerable to bacterial infection. Symptoms of the disorder - most commonly seen in children - often worsen during wintertime. While controlled administration of ultraviolet light, which can stimulate the production of vitamin D in the skin, is a common treatment for severe atopic dermatitis, the possibility that vitamin D deficiency contributes to the seasonal worsening of symptoms had received little consideration prior to the Boston study. That investigation involved only 11 children but provided preliminary support for the hypothesis.

The current study, conducted in collaboration with the National Dermatology Center in Mongolia, enrolled 107 children, ages 2 to 17, from nine outpatient clinics in the capital city of Ulaanbaatar. The participants - all of whom had a history of atopic dermatitis symptoms worsening either during cold weather or around the transition from autumn to winter - were randomly divided into two groups. One group received a daily vitamin D dose of 1000 IU while the other received a placebo - both delivered in odorless, colorless and tasteless drops. Neither the children's parents nor the study investigators knew to which group participants had been assigned.


Standard evaluations of atopic dermatitis symptoms were conducted at the outset of the trial and at the end of the month-long study period, and parents were also asked whether they saw any improvement in their child's condition. At the end of the month, children receiving the vitamin D supplement had an average 29 percent improvement on the primary assessment tool used, compared with 16 percent improvement in the placebo group. Additional assessments - including the report from parents - also showed significantly greater improvement among children receiving vitamin D.

While data gathered at the outset of the study could not determine whether or not participating children were deficient in vitamin D, the authors note that an even larger study of Ulaanbaatar children conducted at the same time found significant vitamin D deficiency in 98 percent of participants, supporting the probability that the children in this study were also deficient. While future studies are needed to assess the value of vitamin D treatment in adults and in children with year-round symptoms, Camargo - a professor of Medicine at Harvard Medical School - says that parents of children with symptoms that worsen in the winter should try a vitamin D supplement for a few weeks when symptoms flare to see if it helps. He encourages parents to discuss this study and their plan with their primary care provider.

 

 

 

سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است.

وب سایت جوم آریا

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است.

وب سایت جوم آریا

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است.

وب سایت جوم آریا

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.

لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.سایت جـوم آریـا یکی از بهترین ارائه دهنده ی قالب های فارسی جوملا و وردپرس است . شما عزیزان می توانید با مراجعه به سایت ما قالب مورد نظر خود را پیدا کنید و با هزینه کمی صاحب یک قالب زیبا و پراز امکانات شوید .لورم ایپسوم متنی است که ساختگی برای طراحی و چاپ آن مورد است. صنعت چاپ زمانی لازم بود شرایطی شما باید فکر ثبت نام و طراحی، لازمه خروج می باشد.


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